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Pathways Recommended:	PI3K/Akt/mTOR

Results for "

K efflux

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (1) Caspase (1) Endogenous Metabolite (1) Fungal (1) P-glycoprotein (2)
By Research Areas:	Cancer (2) Infection (3) Inflammation/Immunology (1) Neurological Disease (2)

7

Inhibitors & Agonists

3

Peptides

3

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Polistes mastoparan	Bacterial	Infection
Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K ⁺ efflux and inhibits cell viability with EC₅₀ of 5 μM .

P-gp inhibitor 18	P-glycoprotein	Cancer
P-gp inhibitor 18 (compound 6G) is a potent inhibitor of P-gp. P-gp inhibitor 18 inhibits rhodamine 123 efflux in the P-gp overexpressed leukemia cells, K562/Dox .

P-gp inhibitor 19	P-glycoprotein	Cancer
P-gp inhibitor 19 (Compound 6i) is a P-gp inhibitor. P-gp inhibitor 19 can inhibit the efflux of rhodamine 123 (HY-D0816) in P-gp-overexpressing leukemia cells K562/Dox and also restore the sensitivity of DOX-resistant cells .

Majoranaquinone	Antibiotic	Infection
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .

Syringomycin E	Fungal	Infection
Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K ⁺ efflux, Ca ²⁺ influx, and changes in membrane potential, and is related to channel formation .

Bilobalide 2 Publications Verification (-)-Bilobalide	Apoptosis Autophagy Endogenous Metabolite	Neurological Disease
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC₅₀ value of 2.3 µM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons .

Sarglaroids F	Caspase	Inflammation/Immunology
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

Cat. No.	Product Name	Target	Research Area

HY-P5901

ChTX-Lq2

Peptides Neurological Disease

ChTX-Lq2 is a Ca ²⁺-activated K ⁺ efflux inhibitor with a K_d of 43 nM .

Polistes mastoparan	Bacterial	Infection
Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K ⁺ efflux and inhibits cell viability with EC₅₀ of 5 μM .

Syringomycin E	Fungal	Infection
Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K ⁺ efflux, Ca ²⁺ influx, and changes in membrane potential, and is related to channel formation .

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